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zipraside (Geodon)

Page history last edited by PBworks 12 years, 9 months ago

Generic: ziprasidone


Trade Name: Geodon


Classifications:  Antipsychotic


Description: Unrelated to the phenothiazines or buytyrophenone classes of antipsychotics. Known to bind to serotonin,dopamine, histamines and a1-adrenergic receptors.


Mechanism of Action: Action is unknown, but is probably related to inhibition of symaptic uptake of serotonin and norepinephrine.


Pharmacokinetics: Onset: not yet determined for IM route

                                                                Peak Effect: not yet determined for IM route

                                                                Duration: not yet determined for IM route

                                                                Hafe-life: 7 hours


Indications: Acute psychosis and Tourette's syndrome.


Contraindictions: patients with hypersensitivity to the drug, patient with QT syndrome.


Precations: Use with caution in patients with history of seizures,strokes, Alzheimer's disease, or with known cardiovascular disease.


Side Effects:  myalgias, somnolence, dizziness, tremor, dyskinesia, extrapyramidal effects(dystonia), tachycardia, postural hypotension, nausea, and dry mouth.


Interastions: Carbazepine (Tegretol) may decrease ziprasidone levels. Interactions may occur with antidysrhythics,antidpressants and ethonal.


Dosage: Ten to 20mg IM up to a maximum dose 40mg


                             Pediatric dosage not indicated





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