Generic: ziprasidone
Trade Name: Geodon
Classifications: Antipsychotic
Description: Unrelated to the phenothiazines or buytyrophenone classes of antipsychotics. Known to bind to serotonin,dopamine, histamines and a1-adrenergic receptors.
Mechanism of Action: Action is unknown, but is probably related to inhibition of symaptic uptake of serotonin and norepinephrine.
Pharmacokinetics: Onset: not yet determined for IM route
Peak Effect: not yet determined for IM route
Duration: not yet determined for IM route
Hafe-life: 7 hours
Indications: Acute psychosis and Tourette's syndrome.
Contraindictions: patients with hypersensitivity to the drug, patient with QT syndrome.
Precations: Use with caution in patients with history of seizures,strokes, Alzheimer's disease, or with known cardiovascular disease.
Side Effects: myalgias, somnolence, dizziness, tremor, dyskinesia, extrapyramidal effects(dystonia), tachycardia, postural hypotension, nausea, and dry mouth.
Interastions: Carbazepine (Tegretol) may decrease ziprasidone levels. Interactions may occur with antidysrhythics,antidpressants and ethonal.
Dosage: Ten to 20mg IM up to a maximum dose 40mg
Pediatric dosage not indicated